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Psychosocial Genomics (PG) is a field of research first proposed by Ernest L. Rossi in 2002.〔Rossi, E. L. (2002). The Psychobiology of Gene Expression: Neuroscience and Neurogenesis in Therapeutic Hypnosis and the Healing Arts. New York: W. W. Norton Professional Books.〕 PG examines the modulation of gene expression in response to psychological, social and cultural experiences.〔Garland, E., & Howard, M.O. (2009) Neuroplasticity, psychosocial genomics, and the biopsychosocial paradigm of the 21st century. Health and Social Work, 34(3): 191-199〕〔Hill, R. (2014). Psychosocial Genomics: A New Vision of the Psychotherapeutic Arts. International Journal of Psychosocial Genonics, 1(1): 38-48.〕 Independent research shows that the experience of novelty,〔Eriksson, P., Perfilieva, E., Björk-Ericksson, T., Alborn, A.-M., Nordborg, C., Peterson, D., & Gage, F. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, (4), 1313–1317.〕 environmental enrichment〔Clelland, C., Choi, M., Romberg, C., Clemenson, G., Fragniere, A., Tyers, P., … Bussey, F. (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science, (325), 210–213 .〕〔Kempermann, G., Kuhn,, G., & Gage, F. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature, (386), 493–495.〕 and exercise〔Loebrich, S., & Nedivi, E. (2009). The Function of Activity-Regulated Genes in the Nervous System. Physiology Review, (89), 1079–1103.〕〔Van Praag, H., Schinder, A., Christie, B., Toni, N., Palmer, T., & Gage, F. (2002). Functional Neurogenesis in the Adult Hippocampus. Nature, (415), 1030–1034.〕〔Van Praag, H., Kempermann, G., & Gage, F. (1999). Running increases cell proliferation and neurogenesis in adult mouse dentate gyrus. Nature Neuroscience, (2), 266–270.〕 facilitates activity and experience dependent gene expression and brain plasticity as well as stem cell healing processes.〔Rossi, E. L., & Rossi, K. L. (2013). Creating New Consciousness in Everyday Life - The Psycho-Social Genomics of Self Creation. Los Osos, CA: Palisades Gateway Publishing.〕〔Rossi, E. L. (2002). The Psychobiology of Gene Expression: Neuroscience and Neurogenesis in Therapeutic Hypnosis and the Healing Arts. New York: W. W. Norton Professional Books.〕 Ernest L. Rossi describes the new science of Psychosocial Genomics: “I call this new perspective on the role of genes as active players in psychological experience psychosocial genomics. Psychosocial genomics focuses on the how the highly personal and subjective states of human consciousness can modulate gene expression in the brain and body for illness or health."〔Rossi, E. L. (2007). Art, Beauty and Truth: The Psychosocial Genomics of Consciousness, Dreams and Brain Growth in Psychotherapy and Mind-Body Healing. In The Breakout Heuristic - The New Neuroscience of Mirror Neurons, Consciousness and Creativity in Human Relationships (pp. 369–381). Phoenix, AZ: The Milton H. Erickson Foundation Press, p. 370〕 This is a top-down approach - from mind to body – that modulates the role of gene expression and brain plasticity in the development of human consciousness which can be perceived as the completion, or dynamic compliment, of the bottom-up approach – direct sensorial and biological responses – as proposed by the ENCODE consortium.〔ENCODE Project Consotium. (2004) The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306(5696): 636-640.〕〔Rossi, E. L., & Rossi, K. L. (2013). Creating New Consciousness in Everyday Life - The Psycho-Social Genomics of Self Creation. Los Osos, CA: Palisades Gateway Publishing.〕 Psychosocial Genomics utilizes in its research various kinds of methods and approaches derived from genomics, neuroscience and culturomics,〔Rossi, E. L., Mortimer, J., & Rossi, K. L. (2012). Therapeutic Hypnosis, Psychotherapy and the Digital Humanities: The Culturomics and Narratives of Hypnosis, 1800-2008. American Journal of Clinical Hypnosis, 3(54), 153–169.〕〔Rossi, E. L., & Rossi, K. L. (2013). Creating New Consciousness in Everyday Life - The Psycho-Social Genomics of Self Creation. Los Osos, CA: Palisades Gateway Publishing.〕 including DNA Microarrays, and computational analysis with the GSEA database.〔Atkinson, D., Iannotti, S., Cozzolino, M., Castiglione, S., Cicatelli, A., Vyas, B., Mortimer, J., Hill, R., Chovanec, E., Chiamberlando, A., Cuadros, J., Virot, C., Kerouac, M., Kallfass, T., Krippner, S., Frederick, C., Gregory, B., Shaffran, M., Bullock, M., Soleimany, E., Rossi, A. C., Rossi, K., & Rossi, E. (2010) A new bioinformatics paradigm for the theory, research, and practice of therapeutic hypnosis. American Journal of Clinical Hypnosis, 53(1): 27-46.〕 ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Psychosocial Genomics」の詳細全文を読む スポンサード リンク
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